α-Synuclein Strains and Their Relevance to Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy Bodies

Like many neurodegenerative diseases, Parkinson’s disease (PD) is characterized by the formation of proteinaceous aggregates in brain cells. In PD, those are formed α-synuclein (αSyn) and considered trademark this disease. addition to αSyn pathological aggregation also detected atypical Parkinsonism, including Dementia with Lewy Bodies (DLB), Multiple System Atrophy (MSA), as well neurodegeneration iron accumulation, some cases traumatic injuries, variants Alzheimer’s Collectively, these (and other) disorders referred synucleinopathies, highlighting relation between type protein misfolding/aggregation. Despite relationships, however, synucleinopathies cover a wide range pathologies, present multiplicity symptoms, arise from dysfunctions different neuroanatomical regions cell populations. Strikingly, deposition occurs types cells, oligodendrocytes being mainly affected MSA, while found neurons PD. If multiple factors contribute development pathology, especially slow-developing disorders, common presence aggregation, both marker potential driver disease, puzzling. review, we will focus on comparing DLB, symptomatology molecular description, role contribution each disorder. We particularly recent evidence for involvement conformational strains discuss reciprocal relationship cellular milieu. Moreover, highlight need effective methodologies strainotyping ameliorate diagnosing capabilities therapeutic treatments.